An examination of the current state

An examination of the current state of hepatotoxic biomarkers indicates that serum F protein, arginase I, and glutathione-S-transferase alpha (GST) levels, all measured by ELISA, may show utility,however, antibody availability and high cost per run may present limitations to widespread applicability in preclinical safety studies.
In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species
and humans and are commercially available. The published literature suggests that these markers, once examined collectively in a large qualification study, could provide additional information relative to serum ALT and aspartate aminotransferase (AST) values.
Since these biomarkers are found in the serum/plasma of treated humans and rats, they have potential to be utilized as bridging
markers to monitor acute drug-induced liver injury in early clinical trials.
© 2007 Elsevier Ireland Ltd. All rights reserved

Results (Indonesian) 1:

Pemeriksaan keadaan saat ini hepatotoksik biomarker menunjukkan bahwa protein serum F, arginase saya, dan glutathione-S-transferase alpha (GST) tingkat, Semua diukur oleh ELISA, mungkin menunjukkan utilitas, namun, antibodi ketersediaan dan biaya tinggi per Jalankan dapat menyajikan keterbatasan untuk penerapan luas dalam studi praklinis keselamatan.Sebaliknya, spidol enzimatik sorbitol dehidrogenase, glutamat dehidrogenase, paraxonase, malate dehidrogenase dan purin nukleosida phosphorylase semua mudah diukur dengan metode fotometrik dan menggunakan reagen yang bekerja di praklinis spesiesdan manusia dan tersedia secara komersial. Literatur yang diterbitkan menunjukkan bahwa penanda ini, setelah diteliti secara kolektif dalam sebuah studi besar kualifikasi, dapat memberikan tambahan informasi dibandingkan serum ALT dan Aspartat nilai-nilai aminotransferase (AST).Karena biomarker ini ditemukan dalam serum/plasma manusia diperlakukan dan tikus, mereka memiliki potensi untuk digunakan sebagai menjembatanipenanda untuk memantau akut obat-induced luka hati dalam uji klinis awal.© 2007 Elsevier Irlandia Ltd Semua Hak, Milik