Another
possible explanation is that the homogenous membrane model
is not applicable for the case when intrinsic membrane
properties are altered due to transmembrane electrical
potential (19), and therefore does not adequately describe
AC iontophoresis at 2.5 V. Transdermal iontophoretic
transport could deviate from the homogenous membrane
model at 2.5 V due to the latter two explanations alone
or a combination of all three explanations. It is clear
from the present study that the iontophoretic transport
pathways at 2.5 V, which can involve electric field inducedpores,
can be more complicated than the conventional
mechanism of iontophoretic transport across either the
appendages or intercellular pathways