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Here we describe the case of a patient (Patient 1) who was hospitalized for non–ST-segment elevation myocardial infarction. After the patient underwent complete revascularization for three-vessel coronary artery disease, double antiplatelet therapy with aspirin and ticagrelor was initiated. Within a few hours after the administration of ticagrelor, the patient began to report dyspnea, particularly at night and in the supine position, despite normal systolic and diastolic left ventricular function and normal pulmonary function. The results of the arterial blood gas analysis were normal, as were outcomes of pulmonary function as assessed by spirometry, which was performed in conformity with the American Thoracic Society–European Respiratory Society standards and included measures of slow vital capacity, forced vital capacity, and forced expiratory volume in 1 second; static lung volumes; and the diffusing capacity of the lung for carbon monoxide.One month later, during a visit for persisting dyspnea, the patient was observed to have an abnormal pattern of periodic breathing, with alternating apneas and hyperventilation. Thus, 24-hour cardiorespiratory monitoring was performed. As shown in Figure 1AFIGURE 1(top), this monitoring revealed the presence of Cheyne
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