7. Glutathione-S-transferase alpha

7. Glutathione-S-transferase alpha as a biomarker of liver toxicity
7.1. GSTα plasma levels can be used as a protein biomarker of liver injury

GSTs are inducible phase II detoxiﬁcation enzymes that catalyze the conjugation of glutathione with reactive metabolites formed during phase I of metabolism. This action reduces toxicity and facilitates urinary excretion (Beckett and Hayes, 1987). Induction of GST synthe- sis is a protective mechanism that occurs in response to xenobiotic exposure.

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7. Glutathione-S-transferase alpha as a biomarker of liver toxicity7.1. GSTα plasma levels can be used as a protein biomarker of liver injuryGSTs are inducible phase II detoxiﬁcation enzymes that catalyze the conjugation of glutathione with reactive metabolites formed during phase I of metabolism. This action reduces toxicity and facilitates urinary excretion (Beckett and Hayes, 1987). Induction of GST synthe- sis is a protective mechanism that occurs in response to xenobiotic exposure.

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7. Glutathione-S-transferase alpha sebagai biomarker toksisitas hati
7.1. GSTα kadar plasma dapat digunakan sebagai biomarker protein hati cedera

GSTs yang diinduksi fase II enzim fi kasi detoxi yang mengkatalisis konjugasi glutation dengan metabolit reaktif yang terbentuk selama fase I dari metabolisme. Tindakan ini mengurangi toksisitas dan memfasilitasi ekskresi urin (Beckett dan Hayes, 1987). Induksi GST synthe- sis adalah mekanisme pelindung yang terjadi dalam menanggapi paparan xenobiotik.

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