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The pathologic hallmarks of the disease in the braininclude neurofibrillary tangles and neuritic plaques made up ofvarious proteins, which result in a shortage of the neurotransmitteracetylcholine. These are primarily located in brain regionsinvolved in learning, memory, and emotional behaviors suchas the cerebral cortex, hippocampus, basal forebrain, andamygdala.11
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