Salbutamol is a beta-(2)-adrenergic

Salbutamol is a beta-(2)-adrenergic agonist and thus it stimulates beta-(2)-adrenergic receptors. Binding of Salbutamol to beta-(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that Salbutamol increases cAMP production by activating adenylate cyclase, and the actions of Salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation. In addition to bronchodilation, Salbutamol inhibits the release of bronchoconstricting agents from mast cells, inhibits microvascular leakage, and enhances mucociliary clearance. It is freely soluble in water, practically insoluble or very slightly soluble in ethanol (96 per cent) and in methylene chloride[[6,7,8]]. The literature survey reveals that few methods are reported for the determination of Salbutamol Sulphate such as Thin layer chromatography, RP isocratic HPLC, UHPLC etc[9,[10,11,12],[13,14]]
MATERIALS AND METHODS .

Results (Indonesian) 1:

Salbutamol adalah agonis beta-(2)-Adrenergik dan dengan demikian merangsang beta-(2)-Adrenergik reseptor. Mengikat Salbutamol beta-(2)-reseptor dalam hasil paru-paru dalam relaksasi otot-otot halus bronkial. Hal ini diyakini bahwa Salbutamol meningkatkan produksi cAMP dengan mengaktifkan adenylate cyclase, dan tindakan Salbutamol dimediasi oleh kamp. AMP siklik intraseluler meningkat meningkatkan aktivitas cAMP-dependent protein kinase A, yang menghambat fosforilasi myosin dan menurunkan konsentrasi kalsium intraseluler. Konsentrasi kalsium intraseluler yang menurunkan yang mengarah ke sebuah relaksasi otot polos dan bronchodilation. Selain bronchodilation, Salbutamol menghambat pelepasan bronchoconstricting agen dari sel mast, menghambat mikrovaskuler kebocoran, dan meningkatkan mucociliary clearance. Ini bebas larut dalam air, praktis tidak larut atau sangat sedikit larut dalam etanol (96 persen) dan metilen klorida [[6,7,8]]. Sastra survei mengungkapkan bahwa beberapa metode dilaporkan untuk penentuan Salbutamol sulfat seperti kromatografi lapis tipis, RP isocratic HPLC, UHPLC dll [9, [10,11,12], [13,14]]BAHAN DAN METODE.