Background and objectiveThe dopamin

Background and objective
The dopamine agonist rotigotine has been formulated in a silicone-based transdermal system for once-daily administration. The objective of the present study was to characterise the mass balance of rotigotine in humans after administration of a single transdermal patch containing radiolabelled [14C]rotigotine and to quantify the pharmacokinetic profiles of total radioactivity and the corresponding rotigotine plasma concentrations.

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Background and objectiveThe dopamine agonist rotigotine has been formulated in a silicone-based transdermal system for once-daily administration. The objective of the present study was to characterise the mass balance of rotigotine in humans after administration of a single transdermal patch containing radiolabelled [14C]rotigotine and to quantify the pharmacokinetic profiles of total radioactivity and the corresponding rotigotine plasma concentrations.

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Results (Indonesian) 2:[Copy]

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Latar belakang dan tujuan
The dopamin agonis rotigotine telah dirumuskan dalam sistem transdermal berbasis silikon untuk administrasi sehari sekali. Tujuan dari penelitian ini adalah untuk mengkarakterisasi keseimbangan massa rotigotine pada manusia setelah pemberian patch transdermal yang berisi radiolabelled [14C] rotigotine dan untuk mengukur profil farmakokinetik radioaktivitas total dan konsentrasi plasma rotigotine yang sesuai.

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Results (Indonesian) 3:[Copy]

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