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Dextromethorphan is a weak, noncompetitive NMDA antagonist that has been used as anantitussive agent. It has been shown to inhibit development of cutaneous secondaryhyperalgesia in people after peripheral burn injury and to reduce temporal summation ofpain40. Several studies investigated the effect of the perioperative administration ofdextromethorphan on acute postoperative pain. Opiate-related adverse effects were similarbetween patients who received dextromethorphan and control patients. Postoperativeadministration of IM dextromethorphan at a dose of 40 mg and oral dextromethorphan (200mg every 8 hours) also were associated with a significant reduction in postoperative opioidconsumption41
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