A similar trend to phenolic contents was observed for flavonoid contends of miracle fruit. The free flavonoid contents in the skin was significantly higher then that in the seed and pulp. The differences in bound flavonoid among the skin, pulp, and seeds were not as great as for free flavonoid. The skin having only 15.91% of the solids contributed about 52% of total flavonoid contreated. The decrease in cholesterolemia was 14% for the animals treated with the fruit skin extract and 12.8% for the animals that received seeds extract, while that for LDL-cholesterol and triglycerides after the administration of extract from grape peel was 12% and 12.4% respectively. These results provide strong suggestive clinical data that fruits with high antioxidants activity, including Miracle Fruit, could be good for health.