other animal species, it causes ins

other animal species, it causes insulin
dependent Diabetes mellitus (called “Alloxan
Diabetes”) in these animals, with
characteristics similar to type 1 Diabetes in
humans. Alloxan is selectively toxic to insulin
producing pancreatic beta cells because it
preferentially accumulates in beta cells
through uptake via the GLUT2 glucose
transporter. Alloxan, in the presence of
intracellular thiols, generates reactive oxygen
species (ROS) in a cyclic reaction with its
reduction product, dialuric acid. The β-cell
toxic action of alloxan is initiated by free
radicals in this redox reaction 5. Mangifera
indica has been reported to have
hypoglycemic effect in both laboratories
animals4,6-8 and human diabetic subjects9
The purpose of this work was to evaluate the
hypo- and anti-hyperglycemic effects of M.
indica in normal and both type of diabetic
model rats and to find out their possible
mode(s) of anti-diabetic action. The purpose
of the present study was to experimentally
assess the anti-diabetic effect of the alcoholic
extract of the leaves of Mangifera indica in
alloxan induced diabetic mice.

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Results (Indonesian) 1: [Copy]

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other animal species, it causes insulindependent Diabetes mellitus (called “AlloxanDiabetes”) in these animals, withcharacteristics similar to type 1 Diabetes inhumans. Alloxan is selectively toxic to insulinproducing pancreatic beta cells because itpreferentially accumulates in beta cellsthrough uptake via the GLUT2 glucosetransporter. Alloxan, in the presence ofintracellular thiols, generates reactive oxygenspecies (ROS) in a cyclic reaction with itsreduction product, dialuric acid. The β-celltoxic action of alloxan is initiated by freeradicals in this redox reaction 5. Mangiferaindica has been reported to havehypoglycemic effect in both laboratoriesanimals4,6-8 and human diabetic subjects9The purpose of this work was to evaluate thehypo- and anti-hyperglycemic effects of M.indica in normal and both type of diabeticmodel rats and to find out their possiblemode(s) of anti-diabetic action. The purposeof the present study was to experimentallyassess the anti-diabetic effect of the alcoholicextract of the leaves of Mangifera indica inalloxan induced diabetic mice.

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Results (Indonesian) 2:[Copy]

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spesies hewan lain, hal itu menyebabkan insulin
dependent diabetes mellitus (disebut "aloksan
Diabetes") pada hewan ini, dengan
karakteristik mirip dengan tipe 1 Diabetes di
manusia. Aloksan adalah selektif beracun untuk insulin
memproduksi sel beta pankreas karena
istimewa terakumulasi dalam sel beta
melalui penyerapan melalui glukosa GLUT2
transporter. Aloksan, dengan adanya
tiol intraseluler, menghasilkan oksigen reaktif
spesies (ROS) dalam reaksi siklik dengan nya
produk reduksi, asam dialuric. -Sel β
tindakan beracun aloksan diawali dengan bebas
radikal dalam reaksi redoks ini 5. Mangifera
indica telah dilaporkan memiliki
efek hipoglikemik di kedua laboratorium
animals4,6-8 dan subjects9 diabetes manusia
Tujuan dari penelitian ini adalah untuk mengevaluasi
hypo - dan efek anti-hiperglikemia M.
indica di normal dan kedua jenis diabetes
Model tikus dan untuk mengetahui kemungkinan adanya
modus (s) tindakan anti-diabetes. Tujuan
dari penelitian ini adalah untuk eksperimen
menilai efek anti-diabetes dari alkohol
ekstrak daun Mangifera indica di
aloksan mencit diabetes yang diinduksi.

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Results (Indonesian) 3:[Copy]

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