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epimorphic regeneration is characterized by formation of two keystructures: a wound epithelium and a blastema. The woundepithelium forms across the exposed wound site within daysfollowing tail loss. Histologically, it is characterized as a hy-perplastic stratified squamous epithelium with a prominentapical thickening The second key element of epimorphic regenerationis the blastema. In the context of Morgan’s originaldefinition, the blastema represents the “proliferation ofmaterial [that] precedes the development of the new part”Since that time, the term has beenrepeatedly refined but almost inevitably includes referenceto the blastema cells being dedifferentiated
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