Captopril is an angiotensin convert

Captopril is an angiotensin converting enzyme (ACE)
inhibitor as antihypertensive treatment with half-life about 2h.
Development of sustained-release dosage form can maintenance
the drug concentration at therapeutic window in long period of
time with constant release. Montmorillonite, zeolite and
hydrotalcite nano-composites were used as drug carrier as
sustained release dosage form. This study aimed to determine the
drug release from nanocomposite of montmorillonite-drug, zeolitedrug
and hydro-talcite-drug. Nanocomposite drug and carriers
were made with the model drug was dispersed in carrier with
matrix system. Matrices used montmorillonite, zeolite and
hydrotalcite with concentrations of 20%, 30% and 40%.
Characterization of matrices were done by testing the physical
properties of the granules and drug release. Dissolution test using
apparatus II USP model with speed rotation of 50rpm of, 900mL of
HCl 0.1N as medium. The results were compared statistically with
one way ANOVA 95% of interval confidence. The results showed
that the difference of matrices and concentrations gave the
difference effect in flow time, compact-tibility, DE360, initial burst
release and maintenance release (p

Results (Indonesian) 1:

Captopril is an angiotensin converting enzyme (ACE)inhibitor as antihypertensive treatment with half-life about 2h.Development of sustained-release dosage form can maintenancethe drug concentration at therapeutic window in long period oftime with constant release. Montmorillonite, zeolite andhydrotalcite nano-composites were used as drug carrier assustained release dosage form. This study aimed to determine thedrug release from nanocomposite of montmorillonite-drug, zeolitedrugand hydro-talcite-drug. Nanocomposite drug and carrierswere made with the model drug was dispersed in carrier withmatrix system. Matrices used montmorillonite, zeolite andhydrotalcite with concentrations of 20%, 30% and 40%.Characterization of matrices were done by testing the physicalproperties of the granules and drug release. Dissolution test usingapparatus II USP model with speed rotation of 50rpm of, 900mL ofHCl 0.1N as medium. The results were compared statistically withone way ANOVA 95% of interval confidence. The results showedthat the difference of matrices and concentrations gave thedifference effect in flow time, compact-tibility, DE360, initial burstrelease and maintenance release (p<0.05). Nanocompositesbetween drug and nanoclays occurred after 60min were shownwith decreasing the drug release rate. Nanocomposite was formedwith the drug molecules adsorb on nanoporous of carrier material.Increasing of clays concentration improved the fluidity andcompactibility, reduced the drug release.Key words: Nanocomposite, clays, drug release

Results (Indonesian) 2:

Captopril adalah enzim angiotensin converting (ACE)
inhibitor sebagai pengobatan antihipertensi dengan paruh sekitar 2 h.
Pengembangan berkelanjutan-release bentuk sediaan kaleng pemeliharaan
konsentrasi obat di jendela terapeutik pada jangka waktu yang panjang
waktu dengan rilis konstan. Montmorillonit, zeolit ​​dan
hidrotalsit nano-komposit yang digunakan sebagai pembawa obat sebagai
bentuk sediaan rilis berkelanjutan. Penelitian ini bertujuan untuk menentukan
pelepasan obat dari nanokomposit dari montmorillonite-obat, zeolitedrug
dan hidro-talcite-obat. Nanokomposit obat dan operator
dibuat dengan model obat itu tersebar dalam carrier dengan
sistem matriks. Matriks digunakan montmorillonite, zeolit ​​dan
hidrotalsit dengan konsentrasi 20%, 30% dan 40%.
Karakterisasi matriks dilakukan dengan menguji fisik
properti dari butiran dan pelepasan obat. Uji disolusi menggunakan
alat II Model USP dengan rotasi kecepatan 50rpm dari, 900 ml dari
HCl 0,1 N sebagai media. Hasilnya dibandingkan secara statistik dengan
one way ANOVA 95% dari interval kepercayaan. Hasil penelitian menunjukkan
bahwa perbedaan matriks dan konsentrasi memberikan
efek perbedaan waktu aliran, kompak-tibility, DE360, ledakan awal
rilis dan rilis pemeliharaan (p <0,05). Nanocomposites
antara obat dan nanoclays terjadi setelah 60menit menunjukkan
dengan menurunnya tingkat pelepasan obat. Nanokomposit dibentuk
. Dengan obat molekul menyerap pada nanoporous bahan pembawa
Peningkatan konsentrasi tanah liat ditingkatkan fluiditas dan
kompaktibilitas, mengurangi pelepasan obat.
Kata kunci: nanokomposit, tanah liat, pelepasan obat