Results (
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The primary unit of analysis was each unique pregnancy during follow-up. We used generalized linear models with generalized estimating equations for the correlation structure to compare the characteristics of donors and nondonors at the time of cohort entry. Pregnancy characteristics and outcomes were analyzed with the use of generalized linear mixed models with a random intercept and random-effects logistic-regression models, which account for the correlation structure within matched sets and in women with more than one follow-up pregnancy. We repeated the analysis of the primary outcome in three prespecified subgroups, which were defined on the basis of the presence or absence of at least one pregnancy before cohort entry, since the risk may be higher in a first pregnancy; the time from cohort entry to pregnancy (≤2 or >2 years), since the risk may be higher in the first 2 years after nephrectomy); and the median age during pregnancy (≤32 years or >32 years), since the risk may be higher among older women. To determine whether subgroup-specific odds ratios differed, we included an interaction term in each model; these analyses were considered exploratory, since the anticipated number of events was small. All analyses were performed with the use of SAS software, version 9.3 (SAS Institute). Continuous data were summarized as medians and interquartile ranges.
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