Study Design We conducted a retrosp

Study Design We conducted a retrospective, matched-cohort study using linked health care databases in Ontario, Canada, where citizens have universal access to hospital care and physician services. The conduct and reporting of the study followed guidelines for observational studies (see Table S1 in the Supplementary Appendix, available with the full text of this article at NEJM.org).18 The study was designed by the authors and approved by a regional ethics committee. To comply with privacy regulations for minimizing the chance of identification of a study participant, numbers of participants are suppressed in the case of 5 or fewer
participants, (reported as ≤5). The data were analyzed by personnel at the Institute for Clinical Evaluative Sciences.
Data Sources We obtained information from four linked databases. The Trillium Gift of Life Network captures information on all living kidney donors in Ontario. To ensure the accuracy and completeness of the data, we manually reviewed the perioperative medical charts of all persons who underwent donor nephrectomy at five major transplantation centers in Ontario from 1992 through 2010. We retrieved data regarding demographic characteristics and vital status from Ontario’s Registered Persons Database. We retrieved data regarding pregnancies and maternal and fetal outcomes from the Discharge Abstract Database of the Canadian Institute for Health Information and the Ontario Health Insurance Plan database. These databases have been used extensively for epidemiologic and health services research, including studies of living kidney donors and maternal and fetal outcomes.19-25 Data were complete for all variables in this study except the surgical technique used for nephrectomy (open or laparoscopic), which was missing for 14% of donors and was reported only for patients with complete data.

Results (Indonesian) 1:

Studi desain kami melakukan penelitian retrospektif, kohort cocok menggunakan database kesehatan terkait di Ontario, Kanada, di mana warga negara memiliki akses universal untuk layanan dokter dan perawatan rumah sakit. Pelaksanaan dan pelaporan studi mengikuti pedoman untuk pengamatan studi (Lihat tabel S1 dalam lampiran tambahan, tersedia dengan teks lengkap dari artikel ini di NEJM.org).18 studi dirancang oleh penulis dan disetujui oleh Komite Bioetika regional. Untuk mematuhi peraturan privasi untuk meminimalkan kemungkinan identifikasi peserta studi, jumlah peserta ditekan dalam kasus 5 atau lebih sedikit peserta, (dilaporkan sebagai ≤5). Data dianalisis oleh personil di Institute for Clinical Sciences evaluatif.Data Sources We obtained information from four linked databases. The Trillium Gift of Life Network captures information on all living kidney donors in Ontario. To ensure the accuracy and completeness of the data, we manually reviewed the perioperative medical charts of all persons who underwent donor nephrectomy at five major transplantation centers in Ontario from 1992 through 2010. We retrieved data regarding demographic characteristics and vital status from Ontario’s Registered Persons Database. We retrieved data regarding pregnancies and maternal and fetal outcomes from the Discharge Abstract Database of the Canadian Institute for Health Information and the Ontario Health Insurance Plan database. These databases have been used extensively for epidemiologic and health services research, including studies of living kidney donors and maternal and fetal outcomes.19-25 Data were complete for all variables in this study except the surgical technique used for nephrectomy (open or laparoscopic), which was missing for 14% of donors and was reported only for patients with complete data.