A 33-year-old woman experienced severe right- or left-sided parietal–temporal throbbing headache accompanied by blurred vision, photophobia, vomiting, and anorexia at a frequency of 1–2 days per month since she was an adolescent. She was diagnosed with migraine without aura and received no prophylactic treatment. One month ago, she exhibited more severe, right-sided, parietal–temporal throbbing headaches characterized by a prolonged duration that increased in frequency to more than 15 days per month. She showed a poor medical response to sumatriptan and naproxen therapy. A few days after sumatriptan and naproxen therapy, she experienced the first MS episode of blurred vision over both the eyes and right facial numbness, which subsided quickly and spontaneously after 24 hours. Because the symptoms subsided quickly after 24 hours, the patient did not come to our outpatient department (OPD) at that time. No objective evidence of alteration of vision or facial sensation was observed. According to our detailed recordings of the patient’s history, she had never experienced these symptoms before.
Because of these new symptoms, the patient underwent brain magnetic resonance imaging (MRI), and some hyperintense lesions in the bilateral periventricular white matter, body of corpus callosum, and periaqueductal grey matter (PAG) were noted on the T2-weighted images. After gadolinium contrast injection, ring enhancement over these lesions was noted on T1-weighted images. In the sagittal view, MS plaques with a typical perpendicular orientation at the callososeptal interface were noted (Dawson’s fingers) (Figure 1). The patient was diagnosed with definite MS according to the McDonald criteria (2010 revision). The MS diagnosis was based on the recording of one episode of MS attack and the evidence of simultaneous gadolinium-enhancing and non enhancing lesions. The patient refused to receive disease-modifying therapy because her symptoms were relieved and the headache subsided gradually.