For gastric digestion 300 U/mL of pepsin (from porcine stomach mucosa, pepsin A, EC 3.4.23.1) was prepared in 0.03 mol/L NaCl, pH = 1.2. Further, simulated intestinal juice was prepared by dissolving 0.05 g of pancreatin (activity equivalent 4 USP) and 0.3 g of bile extract in 35 mL 0.1 mol/L NaHCO3.