Antiretrovirals•Currently implies a

Antiretrovirals
•Currently implies a drug used to treat HIV
•Tenofovir-nucleotide reverse transcriptase inhibitor
•Zidovudine-nucleoside analog –inhibits RT of HIV and is only used orally for AIDS.
-Activated by triple phosphorylation and then binds RT (with100X affinity than for cellular DNA pols).
-Incorporated into the DNA chain, but lacks a 3’OH; so another nucleoside cannot form a 3’-5’-phosphodiester bond DNA chain elongation is terminated.
-Severe adverse effects: anemia, neutropenia, myalgia, nausea, and headaches.
•Stavudine, didanosine, zalcitabine–among other NRTIs.
•Nevirapine, efavirenz–Non nucleoside RTIs -denature RT.

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Antiretrovirals•Currently implies a drug used to treat HIV•Tenofovir-nucleotide reverse transcriptase inhibitor•Zidovudine-nucleoside analog –inhibits RT of HIV and is only used orally for AIDS.-Activated by triple phosphorylation and then binds RT (with100X affinity than for cellular DNA pols).-Incorporated into the DNA chain, but lacks a 3’OH; so another nucleoside cannot form a 3’-5’-phosphodiester bond DNA chain elongation is terminated.-Severe adverse effects: anemia, neutropenia, myalgia, nausea, and headaches.•Stavudine, didanosine, zalcitabine–among other NRTIs.•Nevirapine, efavirenz–Non nucleoside RTIs -denature RT.

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ARV
• Saat menyiratkan obat yang digunakan untuk mengobati HIV
• Tenofovir-nucleotide reverse transcriptase inhibitor
• analog Zidovudine-nucleoside -inhibits RT HIV dan hanya digunakan secara oral untuk AIDS.
-Activated Oleh fosforilasi tiga dan kemudian mengikat RT (with100X afinitas daripada untuk seluler pols DNA).
-Incorporated ke dalam rantai DNA, tetapi tidak memiliki 3'OH a; sehingga nucleoside lain tidak dapat membentuk 3'-5'-fosfodiester rantai DNA obligasi perpanjangan diakhiri.
efek -Severe merugikan. anemia, neutropenia, mialgia, mual, dan sakit kepala
. • Stavudine, ddI, zalcitabine-antara NRTI lain
• Nevirapine , efavirenz-Non nucleoside ISr -denature RT.

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Results (Indonesian) 3:[Copy]

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