Considering that its strength and elastic properties can be adjusted by changing its monomer contents, PHBHHx could be tailored to meet the requirements for regenerating both bone and soft tissues. PHBHHx, with its excellent
mechanical and thermal properties, has been used as a scaffold for tissue-engineered cardiovascular products
prepared and modified PHBHHx by ammonia-plasma treatment and fibronectin coating and then inoculated human umbilical vein endothelial cells (HUVECs) and rabbit aorta smooth muscle cells on the surface of the modified PHBHHx scaffold (PFn-PHBHHx).
They found that HUVECs proliferated more on the PFn-PHBHHx than the PHBHHx surface and formed a confluent monolayer 3 days after seeding.
This finding suggests that PFn-PHBHHx may be a good material as a luminal surface of vascular grafts.