Antiretrovirals•Currently implies a

Antiretrovirals
•Currently implies a drug used to treat HIV
•Zidovudine-nucleoside analog –inhibits RT of HIV and is only used orally for AIDS.
-Activated by triple phosphorylation and then binds RT (with100X affinity than for cellular DNA pols).
-Incorporated into the DNA chain, but lacks a 3’OH; so another nucleoside cannot form a 3’-5’-phosphodiester bond DNA chain elongation is terminated.
-Severe adverse effects: anemia, neutropenia, myalgia, nausea, and headaches.
•Indinavir-protease inhibitors. Inhibit the synthesis of essential viral proteins (e.g., RT) by viral-specific proteases.

Results (Indonesian) 2:

ARV
• Saat menyiratkan obat yang digunakan untuk mengobati HIV
analog • Zidovudine-nucleoside -inhibits RT HIV dan hanya digunakan secara oral untuk AIDS.
-Activated Oleh fosforilasi tiga dan kemudian mengikat RT (with100X afinitas daripada pols DNA sel).
-Incorporated Ke rantai DNA, tetapi tidak memiliki 3'OH a; sehingga nucleoside lain tidak dapat membentuk 3'-5'-fosfodiester rantai DNA obligasi perpanjangan diakhiri.
efek -Severe merugikan. anemia, neutropenia, mialgia, mual, dan sakit kepala
• inhibitor Indinavir-protease. Menghambat sintesis protein virus yang penting (misalnya, RT) oleh protease virus-spesifik.