Results (
Thai) 2:
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This study showed a significant improvement in weight
which reached a plateau after 6 months with no differences
between treatments (as planned). The 13% difference
in urinary urea at 12 months confirms that the
planned dietary protein separation was maintained. It has
been suggested that an HPD will have a negative effect on
renal function in T2DM participants with renal impairment;
but the evidence is scant and there is not sufficient
evidence to recommend a protein intake lower than usual
intake in T2DM with mild renal impairment nor is there
evidence of harm with a higher intake [9,10]; however in
this study renal function showed a trend towards a
beneficial effect of weight loss in both those patients with
hyperfiltration and those with slightly impaired GFR
regardless of diet allocation.
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