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In a cohort of infants living in New England, van Strien et al found that infants exposed to
more than 17.4 ppb NO2 had significantly increased risk for respiratory diseases compared with those exposed to lower levels of NO2 [12]. Furthermore, in Santa Clara, Calif, NO2 levels were associated with childhood asthma exacerbations [13]. Chauhan et al [14] showed that increased indoor NO2 exposure was associated with increased severity of viral-induced exacerbation of asthma. There were about 23 million people living in Taiwan, an island of 12600 square miles, in 2004. The most popular modes of transportation were motorcycles and cars because of the lack of rapid mass transit systems, especially in central Taiwan. People frequently used gasoline-powered vehicles, which resulted in mean air concentrations of NO2 more than 20 ppb and as high as 26 ppb in 7 months in 2004
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