The zinc-PCA is a combination of zinc and PCA (obtained by cyclization of the L-glutamic acid, amino acid by veg- etal origin). This compound reduces unwanted sebum and antidandruff also inhibits activator protein-1 pro- duction (involved in producing collagenase and collagen degradation). In addition, PO is an effective antidandruff active which its solubility in cosmetic products depends on pH=5 - 8.This component is antidandruff, antibacte- rial and antifungal due to its effect on the yeast cell divi- sion. Also, PO is an antifungal ingredient as it inhibits the sodium-potassium channel and reduces dandruff.