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Fillers can be divided into two main groups; temporary ones made from hyaluronic acid, which is eventually absorbed into the body, and more permanent ones made from other materials that can remain in the body for many years
'I have seen a 40-year-old woman patient who suddenly lost the skin between her eyebrows because an unqualified person had injected dermal filler into her frown lines, accidentally blocking an artery,' he says.
A less damaging, but still upsetting, result is the Tyndall Effect. It happens when temporary hyaluronic acid fillers, which reflect light on a particular spectrum, are injected too close to the surface of the skin, producing a translucent blue discolouration.
'Every kind of procedure intended to alter your appearance needs careful thinking about - it should not be something you do during lunchtime, or because you are lured by discounts'
Pressure is increasing for tighter regulation so only properly qualified, trained and accredited professionals can administer the treatment and the fillers are properly tested.
In January, Andrew Lansley, then Health Secretary, promised a review of the cosmetics industry and it was launched in August by Sir Bruce Keogh, the medical director of the NHS. The recommendations are expected in March.
'Every kind of procedure intended to alter your appearance needs careful thinking about - it should not be something you do during lunchtime, or because you are lured by discounts,' says Dr Alex Clarke, of Royal Free Hospital's department of plastic and reconstructive surgery.
Some experts are claiming fillers could cause a healthcare crisis bigger than the faulty PIP breast implants in 2010.
Yet, sadly for women like Mary and Marie, the call for regulation has come too late.
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