The study was a randomized, double-blind,
placebo-controlled, crossover trial. The I/R trial was performed at baseline and the study participants were then randomized to consume
either the tart cherry juice (Cherrypharm) or placebo at a dose of 240 mL
(8 fluid ounces) twice daily for 14 d. During the last 5 d of the
intervention (d 10–14), the study participants were asked to collect a
first-morning urine sample for measurement of oxidative stress markers.
The I/R trial was repeated at the end of the 14-d intervention. Between
treatments, there was a 4-wk washout during which study participants
were asked to continue their normal diet but without juice supplemen-
tation. After the washout period, the I/R trial was repeated a 3rd time
and the study participants then crossed over to the opposite treatment
group, tart cherry juice or placebo, for 14 d. Once again, they collected a
first morning urine sample during the last 5 d of the intervention and then
completed the final (and 4th) I/R trial.