Oblivious Impact. AI systems may be insensitive to impact. These systems may fail to account for the false-positive and false-negative predictions in relation to the clinical context. Li et al36 applied a deep learning algorithm to detect referable diabetic retinopathy in a data set of 71 043 retinal images. In this study, the algorithms had a high sensitivity and specificity of 92.5% and 98.5%, respectively. Misclassification of mild or moderate diabetic reti- nopathy accounted for 85.6% of false-positive cases, whereas undetected intraretinal microvascular abnormalities accounted for 77.3% of all false-negative cases. To be able to achieve more accurate and error-free systems, the systems should be able to identify the outliers and accordingly adjust their confidence of diagnosis.