The adopted strategy to overcome fouling problems consisted in the application of an appropriate pulse potential waveform. As the cathodic peak potential for quinone reduction equals +0.1700.001V vs. Ag, AgCl/KClsat (Fig. 1), the detection potential was set much more negative, at 0.00 V vs. Ag, AgCl/KClsat to ensure faster reduction rate. The optimum cleaning potential for in situ regeneration of the electrode surface was found to be +1.40 V vs. Ag, AgCl/KClsat. According to data reported in the literature, fouled electrodes could be reactivated by anodic polarization at high potentials [50–57]. It is considered that electrode regeneration could be attributed to the simultaneous action of the produced hydroxyl radicals and the released oxygen which provoke