From the above results, we concluded that dietary supplement
with 1% CGMP significantly alleviated the decrease in growth performance
caused by E. coli infection. The beneficial effects of CGMP
may rely on the inhibition of pathogen overgrowth and specific
adhesion to K88 strain, which prevented intestinal morphology
from being damaged, inhibited the increase of intestinal permeability,
and avoided the inflammatory responses induced by pathogen
invasion. These results suggested that CGMP might be used to
develop an effective feed additive to protect the weaning piglets
from PWD.