showed that expression of human MTN

showed that expression of human MTNR1A in COS-7 cells resulted in high-affinity binding of radiolabeled melatonin with pharmacologic characteristics similar to endogenous high-affinity receptors. Functional studies of mouse fibroblasts stably expressing sheep Mtnr1a showed that the mammalian melatonin receptor is coupled to inhibition of adenylyl cyclase (see 103072) through a pertussis toxin-sensitive mechanism.

Results (Indonesian) 1:

menunjukkan bahwa ekspresi MTNR1A manusia dalam sel-sel COS-7 mengakibatkan tinggi-afinitas mengikat pelacak radiolabeled melatonin dengan farmakologis karakteristik mirip endogen afinitas tinggi reseptor. Fungsional studi mouse fibroblas stabil mengungkapkan domba Mtnr1a menunjukkan bahwa reseptor mamalia melatonin yang digabungkan ke penghambatan adenylyl cyclase (Lihat 103072) melalui mekanisme toksin-sensitif Pertusis.