Steroid-Induced Cataract
steroid-induced cataract are also located in the posterior subcapsular region. Dosage and the duration of steroid use appear to be controlling factors. although individuals may have varying levels of susceptibility. Children develop such cataracts at a faster rate than do adults, Reversal of the cataract can occur but this is rare. The opacity appears to be formed of undifferentiated epothelial cells at the interface of the posterior cortex and capsule. These misplaced cells (which should only be present in the lens epithelium) display aberrant behavior. The undifferentiated cells may have migrated from the preequatorial area. influenced by a change in the cocentration of growth factors. The growth factors governing nitosis, nigration, and differentiation are obtained from aqueous and reside in the lens capsule. If steroids influence production of these growth factors that are present in the aqueous, and the concentration and location in the capsule is altered, cellular processes can be affected.