Objective: To evaluate antibacterial activity of the Indonesian water soluble green tea extract, Camellia sinensis, against clinical isolates of methicillin-resistant Staphylococcus aureus
(S. aureus) (MRSA) and multi-drug resistant Pseudomonas aeruginosa (MDR-P. aeruginosa). Methods: Antimicrobial activity of green tea extract was determined by method and the minimum inhibitory concentration (MIC) was determined by ththee dtiwsocf odlidf fsuesriioanl mbruoltthi- ddirluugti orenssi smtaentth coldin. iTchael itseosltaetdes boafc Ste. raiau rueusisn agn din P t.h aise rsutguidnyo swae, roeb ttahien esdta fnrdomar dL asbtroariantos rayn odf Clinical Microbiology, Faculty of Medicine, University of Indonesia. Results: The results showed that the inhibition zone diameter of green tea extracts for S. aureus
AinThCibCi ti2o5n9 2z3o naen dd iaMmReStAer wfoerr Pe .( 1a8e.r9u7g0i依n0o.s2a8 7A) TmCmC ,2 7a8n5d3 a(1n9d.1 M30D依R0.-2P50. ) amermug rinesopsae cwtievreel (y1.7 .W55h0i依le0. 3t9h3e) mm and (17.670依0.398) mm respectively. The MIC of green tea extracts against S. aureus ATCC 25923 and MRSA were 400 μg/mL and 400 μg/mL, respectively, whereas the MIC for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were 800 μg/mL, and 800 μg/mL, respectively. Conclusions: Camellia sinensis leaves extract could be useful in combating emerging drug- resistance caused by MRSA and P. aeruginosa.