Results (
Thai) 1:
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Several methods have been described for quantification of MA,
THC and their metabolites in oral fluid. Immunochemical methods,
mainly ELISA, are generally used as a screening method [4]. Positive
samples from the screening tests are confirmed by a more specific
technique such as gas chromatography–mass spectrometry (GC–MS)
[5] and liquid chromatography–mass spectrometry (LC–MS) [6].
Previously we established an analytical method for MA and its main
metabolite amphetamine (AM) in oral fluid [7]. In this study, we
present an analytical method using GC–MS to determine THC and its
main metabolite 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid
(THC-COOH) in oral fluid. The validated method was applied to actual
oral fluid samples collected from drug abuse suspects and their results
were compared with those in urine. The stability of THC and THCCOOH
in oral fluid stored in different containers was also investigated.
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