Clozapine and olanzapine are considered the worst offenders for contributing to hyperglycemia, dyslipidemia, and weight gain. Intermediate effects are seen with risperidone and quetiapine, while ziprasidone and aripiprazole are considered to convey the smallest relative risk Interestingly, the relative risks of these agents parallel their relative effects on weight gain. A report of 1-year treatment data compiled from industry-sponsored trials showed more weight gain with clozapine and olanzapine (~12 kg) when compared to quetiapine and risperidone (~2 to 3 kg), aripiprazole (slightly less than quetiapine or risperidone), or ziprasidone (~2 to 3 kg weight loss)