Of the PCCs that are discontinued f

Of the PCCs that are discontinued for organ toxicity, up to half are due to hepatotoxic effects including necro-sis, steatosis, cholestasis, proliferation, inflammation,and bile duct hyperplasia. Likewise, the most frequently
cited reason for withdrawal of an approved drug is toxicity and often hepatotoxicity is the source of concern (Xu et al., 2004).

Results (Indonesian) 1:

Dari PCCs yang dihentikan untuk organ toksisitas, sampai setengah adalah karena hepatotoksik efek termasuk energi-sis, steatosis, kolestasis, proliferasi, peradangan, dan saluran empedu hiperplasia. Demikian juga, yang paling seringdikutip alasan untuk penarikan obat disetujui toksisitas dan sering hepatotoksisitas adalah sumber keprihatinan (Xu et al., 2004).