In quest of cheap anti HIV drugs, m

In quest of cheap anti HIV drugs, molecular docking studies with
HIV-1RT (PDB ID 1FK9) were carried out using certain succinic acid
derivatives. One of the derivatives-2-(diphenylmethylene)succinic acid
was found to have binding energy and docking pattern comparable to
the originally docked efavirenz molecule. This molecule has been
predicted theoretically to be non-toxic. Five drug molecules similar in
druggability to this molecule , but used in other diseases , were
identified and their molecular docking results on 1FK9 have also been
reported .
Keyword: Molecular docking, HIV-1RT,1FK9, succinic derivatives,
quick prop, druggability.

Results (Indonesian) 2:

Dalam pencarian murah obat anti HIV, studi docking molekular dengan
HIV-1RT (PDB ID 1FK9) dilakukan dengan menggunakan asam suksinat tertentu
derivatif. Salah satu asam suksinat turunan-2- (diphenylmethylene)
ditemukan memiliki energi mengikat dan pola docking sebanding dengan
molekul efavirenz awalnya berlabuh. Molekul ini telah
diperkirakan secara teoritis menjadi tidak beracun. Lima molekul obat sejenis di
druggability untuk molekul ini, tetapi digunakan pada penyakit lain, yang
diidentifikasi dan hasil docking molekular mereka pada 1FK9 juga telah
dilaporkan.
Keyword: docking Molekuler, HIV-1RT, 1FK9, turunan suksinat,
prop cepat, druggability.