The essential nutrients that necessary for the body act against oxidation in the human body. Oxidation reaction is a natural reaction. That occurs because cells in the body have used the power in the process of metabolism to obtain various substances used to advantage in living. In addition, it also obtains the substance called Free radical. The human body cannot create vitamin E, must be obtained from the external that is diet and supplements, both found in vegetable oil, wheat and bean. Nowadays, vitamin E is commonly used in cream to nourish and also increase moisture and elasticity to the skin. However Vitamin E or Alpha-tocopherol are unstable and lose condition when exposed to the air, heat and sun. So it requires a derivative of vitamin E acetate and vitamin E succinate instead which is more stable form. Natural Vitamin E is more effective than the synthesis about 36% due to vitamin E derived from natural will stay in the tissue longer than synthesis vitamin E.