Diabetes mellitus is the most commo

Diabetes mellitus is the most common
endocrine disorder that affects more than 100
million people worldwide. Diabetes is a
heterogeneous primary disorder of
carbohydrate metabolism and it has affected
around 171 million people worldwide in 2000
which may increase to 366 million by 2030 1.
Major limitations of the oral anti-diabetic
agents are their side effects and cost of the
therapy. The high cost of modern treatment of
diabetes indicates a great need for the
development of alternative strategies for
prevention and treatment of diabetes. Origin
and natural products plays an important role in
drug development programs in the
pharmaceutical industry and plants are the
basic source of knowledge for modern
medicine2.There have been many studies on
hypoglycaemic plants and a great variety of
compounds have been isolated, but the main
bottleneck is the further development of such
leads into clinically useful medicines and
especially phyto-medicines are adequate
nutritional supplements, which would be of
direct benefits to patients. Mangifera indica
commonly known as mango is large
evergreen tree of tropical and subtropical
region and has been used for traditional
medicine by a number of peoples for
centuries. In Ayurvedic literature of India,
different parts of this plant have been
recommended as a remedy having antidiabetic,
anti-oxidant, antiviral, hypolipidemic
effects. The extract showed a powerful
scavenging activity of hydroxy radicals and
acted as a chelator of iron. It also showed a
significant inhibitory effect on the peroxidation
of rat brain phospholipid and prevented DNA
damage caused by bleomycin or copperphenenthroline
systems3. The aqueous
extracts of the leaves of M. indica possess
hypoglycaemic activity4. Alloxan is a toxic
glucose analogue, which selectively destroys
insulin producing β-cells in the pancreas
.When administered to rodents and many

Results (Indonesian) 1:

Diabetes mellitus adalah yang paling umumgangguan endokrin yang mempengaruhi lebih dari 100juta orang di seluruh dunia. Diabetesheterogen utama gangguanmetabolisme karbohidrat dan telah mempengaruhisekitar 171 juta orang di seluruh dunia pada tahun 2000yang dapat meningkatkan 366 juta oleh 2030 1.Keterbatasan utama yang anti-diabetik lisanagen yang efek samping dan biaya merekaterapi. Biaya tinggi pengobatan modernDiabetes menunjukkan kebutuhan besar untukpengembangan strategi alternatifpencegahan dan perawatan diabetes. Asaldan produk alami memainkan peran penting dalamobat program pembangunan diindustri farmasi dan tanamandasar sumber pengetahuan modernmedicine2. Telah ada banyak penelitian padahypoglycaemic tanaman dan berbagai macamsenyawa telah terisolasi, tapi utamakemacetan adalah pengembangan lebih lanjut sepertimembawa obat-obatan secara klinis berguna danterutama phyto-obat-obatan memadaisuplemen gizi, yang akanmanfaat langsung kepada pasien. Mangifera indicadikenal seperti mangga besarpohon cemara tropis dan subtropiswilayah dan telah digunakan untuk tradisionalKedokteran oleh sejumlah orang untukberabad-abad. Dalam sastra Ayurvedic India,Bagian yang berbeda dari tanaman ini telahdirekomendasikan sebagai obat yang memiliki antidiabetic,anti-oksidan, antivirus, hypolipidemicefek. Ekstrak menunjukkan yang kuatmengais-ngais aktivitas hidroksi radikal danbertindak sebagai chelator besi. Itu juga menunjukkanEfek penghambatan signifikan pada peroxidationfosfolipid otak tikus dan mencegah DNAkerusakan yang disebabkan oleh bleomycin atau copperphenenthrolinesystems3. Larutanekstrak daun M. indica memilikihypoglycaemic activity4. Alloxan adalah beracunglukosa analog, yang selektif menghancurkanβ-sel dalam pankreas memproduksi insulin. Ketika diberikan kepada hewan pengerat dan banyak