Chloramphenicol•Broad-spectrum.•Ser

Chloramphenicol
•Broad-spectrum.
•Serious side-effects: bone marrow aplasia, suppression of RBCs, WBCs, encephalopathy, optic neuritis.
•So, periodic blood counts required, esp in high doses.
•Large Vd, including CNS.
•Inhibits the actions of other drugs and may incr the actions of phenytoin, sulphonlureas, and warfarin.
•Neonates cannot met the drug rapidly accum ‘grey baby’ syndrome (pallor, abdominal distension, vomiting, and collapse).

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Chloramphenicol•Broad-spectrum.•Serious side-effects: bone marrow aplasia, suppression of RBCs, WBCs, encephalopathy, optic neuritis.•So, periodic blood counts required, esp in high doses.•Large Vd, including CNS.•Inhibits the actions of other drugs and may incr the actions of phenytoin, sulphonlureas, and warfarin.•Neonates cannot met the drug rapidly accum ‘grey baby’ syndrome (pallor, abdominal distension, vomiting, and collapse).

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Kloramfenikol
• spektrum luas.
• Serius efek samping. Sumsum tulang aplasia, penindasan sel darah merah, leukosit, ensefalopati, optik neuritis
• Jadi, jumlah darah periodik diperlukan, esp dalam dosis tinggi.
• Besar Vd, termasuk CNS.
• Menghambat tindakan obat lain dan mungkin incr tindakan fenitoin, sulphonlureas, dan warfarin.
• Neonatus tidak dapat bertemu obat cepat accum 'grey bayi sindrom (pucat, distensi abdomen, muntah, dan keruntuhan).

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Results (Indonesian) 3:[Copy]

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