There are two prerequisites for dev

There are two prerequisites for developing C difficile
associated diarrhoea: disruption of the normal
gastrointestinal flora, causing diminished colonisation
resistance favouring C difficile, and acquisition
of the organism from an exogenous source.
Other factors include host susceptibility, virulence
of the C difficile strain concerned, and the nature
and extent of antimicrobial exposure.3
In normal people there are more than 500
species of bacteria in the colon. A gram of faeces
normally contains up to 1012 bacteria that resist
colonisation and impair multiplication of C
difficile. Lactobacilli and group D enterococci
display most antagonistic activity,8 and eradication
or reduction of such bacteria by antibiotics
creates an environmental vacuum for C difficile to
fill. People have significant variations in their
intestinal microflora and the elderly population
are most at risk of C difficile diarrhoea, possibly
because their protective bacteroides diversity is
more likely to be affected by antibiotics, which
then permit growth of C difficile.

Results (Indonesian) 1:

Ada dua prasyarat untuk mengembangkan C difficileterkait diare: gangguan normalflora pencernaan, menyebabkan berkurang kolonisasiperlawanan yang menguntungkan C difficile, dan akuisisiorganisme dari sumber eksogen.Faktor-faktor lain termasuk Hospes, virulensistrain difficile C yang bersangkutan, dan sifatdan luasnya antimikroba exposure.3Pada orang normal ada lebih dari 500spesies bakteri dalam usus besar. Gram kotoranbiasanya berisi hingga 1012 bakteri yang menolakKolonisasi dan merusak perkalian cdifficile. Laktobasili dan Grup D enterococciMenampilkan paling antagonis aktivitas, 8 dan Pemberantasanatau Pengurangan bakteri seperti itu oleh antibiotikmenciptakan vakum lingkungan untuk C difficile untukisi. Orang memiliki variasi yang signifikan di merekamicroflora usus dan populasi orang tuaadalah paling berisiko dari C difficile diare, mungkinkarena keragaman bacteroides pelindung merekalebih mungkin akan terpengaruh oleh antibiotik, yangkemudian mengizinkan pertumbuhan C difficile.