for example, dysregulation of the hypothalamic-pituitary-adrenal axis, which is found in diabetics.Third, childhood trauma may impact brain structures that may moderate response to life events, and depressed diabetics have been shown to have focal subcortical biophysical abnormalities in the head of the caudate nucleus and high prefrontal glutamate levels. 45–49 Fourth, childhood trauma may play a role in the development of neuroticism and hostility personality dimensions known to be predisposing to depression.