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Nucleotides are always added to the growing strand at the 3' end (end with free -OH group).The hydroxyl group reacts with the phosphate group on the 5' C of the deoxyribose so the chain growsEnergy is released when the bound linking 2 of the 3 phosphate groups to the deoxyribonucleoside triphosphate breaks Remaining phosphate group becomes part of the sugar-phosphate backbone
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