In the current study, we noted that
68% of the women who discontinued
antidepressant treatment proximate to
conception relapsed during pregnancy;
of those who relapsed, approximately
50% did so in the first trimester
of pregnancy and 90% experienced
recurrence of depression by the end of
the second trimester. This is compared
with the 26% of women who re-
in reproductive-age women, the
prevalence of antidepressant use in this
population, and the frequency of unplanned
pregnancy, the ability to inform
patients about risk of depressive
relapse if either discontinuation or
maintenance of treatment is pursued as
a clinical course has significant implications