Results (
Indonesian) 1:
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Discussion
The causes leading to ICH and hematoma growth in patients who are on OAT are not completely understood. Potential mechanisms include the unmasking of pre-existing subclinical intracerebral bleedings by the use of OAT.16 The underlying causes of spontaneous ICH and OAT-ICH might be the same, with OAT being only a precipitating factor.17 It is also possible that OAT directly causes ICH by interfering with the synthesis of VAK-dependent clotting factors. Despite the lack of prospective data, rapid reversal of increased INR is the initial treatment of choice to prevent hematoma enlargement.2,11,18–20 However, none of the treatment regimens, including VAK, FFP, or PCC, have been proven to be more effective than another.
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