DiscussionThe causes leading to ICH and hematoma growth in patients wh translation - DiscussionThe causes leading to ICH and hematoma growth in patients wh Indonesian how to say

DiscussionThe causes leading to ICH

Discussion
The causes leading to ICH and hematoma growth in patients who are on OAT are not completely understood. Potential mechanisms include the unmasking of pre-existing subclinical intracerebral bleedings by the use of OAT.16 The underlying causes of spontaneous ICH and OAT-ICH might be the same, with OAT being only a precipitating factor.17 It is also possible that OAT directly causes ICH by interfering with the synthesis of VAK-dependent clotting factors. Despite the lack of prospective data, rapid reversal of increased INR is the initial treatment of choice to prevent hematoma enlargement.2,11,18–20 However, none of the treatment regimens, including VAK, FFP, or PCC, have been proven to be more effective than another.
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Discussion
The causes leading to ICH and hematoma growth in patients who are on OAT are not completely understood. Potential mechanisms include the unmasking of pre-existing subclinical intracerebral bleedings by the use of OAT.16 The underlying causes of spontaneous ICH and OAT-ICH might be the same, with OAT being only a precipitating factor.17 It is also possible that OAT directly causes ICH by interfering with the synthesis of VAK-dependent clotting factors. Despite the lack of prospective data, rapid reversal of increased INR is the initial treatment of choice to prevent hematoma enlargement.2,11,18–20 However, none of the treatment regimens, including VAK, FFP, or PCC, have been proven to be more effective than another.
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Diskusi
yang menyebabkan menyebabkan pertumbuhan ICH dan hematoma pada pasien yang berada di OAT tidak sepenuhnya dipahami. Mekanisme potensial termasuk unmasking sudah ada pendarahan intraserebral subklinis dengan menggunakan OAT.16 Penyebab yang mendasari spontan ICH dan OAT-ICH mungkin sama, dengan OAT hanya menjadi pencetus factor.17 Hal ini juga mungkin bahwa OAT secara langsung menyebabkan ICH dengan mengganggu sintesis faktor pembekuan VAK tergantung. Meskipun kurangnya data prospektif, pembalikan cepat meningkat INR adalah pengobatan awal pilihan untuk mencegah hematoma enlargement.2,11,18-20 Namun, tak satu pun dari rejimen pengobatan, termasuk VAK, FFP, atau PCC, telah terbukti lebih efektif daripada yang lain.
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