Table 2 Quotations to illustrate symptom-related and quality of life related outcomes Symptom-related outcomes Safety (of self/others) • 'Her behaviour became so risky in a way, and it was so difficult with her at home' [C50] • When he's psychotic... he's a danger to himself and he could be a danger to other people.' [C26827] • You're at risk the whole time and a bit more vulnerable. [C07)] Fear/distress/pain • 'It's an effort and it's almost a pain, it's almost like a physical pain for him to stay normal.' [C09) I know that he's distressed by the psychosis. You know he's seeing things that are really awful... If I look back, when medication was introduced [um] he probably was less distressed.' [C24] • I think the worst thing was that... why should he have so much suffering? [C13] Insight • He's doing very well at the moment although he's in hospital. But the reason is that he has total insight... He knows what's real... that has been the biggest progress' (C07] • To recognise that it's his illness that's giving him his thoughts, that's giving him his voices. [C09] . • "She knows the difference between a paranoid thought and quote, a normal thought. So she knows when these thoughts are coming... and can begin to tackle them.' [C22] • He's come to the realisation that he does need an anti-psychotic.' (C11] Quality of life Social acceptability - (Medication allows her) to behave appropriately and you know [um]... in family situations. [C04805) • 'Medication's allowing him to be in the community and it's allowing the community to be safe' (C12] • 'Unusual behaviour. Is there anything that can be done about that?' [C20]