Out of 106 students, 65 students were the 3rd year who enrolled in Medicinal chemistry II, while 41 students were the 4th year who enrolled in Medicinal chemistry IV in the academic year of 2015. All of them were divided into 10 groups, and each group received a different problem, which selected from clinical data resource. To evaluate their knowledge, pre and post assessment might be conducted. The satisfaction of the integration project was evaluated by using 5-Likert scale questionnaires. The paired t - test was used for comparison of pre-test and post-test.