In F. chinensis, FcSP, a compliment C1r/C1s-Uegf-Bmp1 (CUB) domaincontaining SP (FcCUBSP), and FcSPHs, including a masquerade SPH (FcMas), and single domain-containing SPHs (FcSPH and FcSPH2), are produced in the hemocytes that infiltrated the gills and the expression of all FcSPs and FcSPHs are up-regulated in response to pathogen challenge [126,127].