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Pooled effect size across studies
Pooled effect size were calculated with the comprehensive Meta-analysis (CMA) software version 2.0 on windows (biostat, Englewood, new jersey, USA). A random effects model was used to compute weighted mean effect size, because we expected true population effect sizes to vary across studies owing to differences in sample, methodology and treatment. The random effects model results in more conservative results and broader 95% confidence interval than the fixed effects model. Heterogeneity of effect sizes within and between subsamples was calculated using the Q statistic. Pooled effect sizes were also recalculated with outliers removed when the individual effect sizes did not overlap with the confidence interval.
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