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The discovery•Van Leeuwenhoeck(1677) discovereand described single-celled organisms (animalcules) with his handcrafted microscopes•Their different activitesand functions were identified after approximately 200 years laterfermentations, understanding diseases in humans and animals and in agriculture•Prof. Charles E. Sedillot(1804-1833):pioneers of modern medicine, surgery, anaesthesiology, histopathology and infectiologyunderstood the existence and action of microorganisms, which he termed as microbes while studying the development of post-operative infections
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