AcetylcholineThe neurotransmitter a

Acetylcholine
The neurotransmitter acetylcholine (Ach) is responsible for
transmitting messages between certain nerve cells in the
brain. In AD, the plaques and tangles damage these pathways,
leading to a shortage of Ach, resulting in learning and memory
impairment.15 The loss of Ach activity correlates with the
severity of AD. The basis of pharmacologic treatment of AD
has been to improve cholinergic neurotransmission in the
brain. Acetylcholinesterase is the enzyme that degrades Ach
in the synaptic cleft. Blocking this enzyme leads to an increased
level of Ach with a goal of stabilizing neurotransmission.16 In
the United States, the four cholinesterase inhibitors
approved for the treatment of AD are tacrine, donepezil,
rivastigmine, and galantamine.

Results (Indonesian) 2:

Acetylcholine
The neurotransmitter asetilkolin (Ach) bertanggung jawab untuk
transmisi pesan antara sel-sel saraf tertentu dalam
otak. Dalam AD, plak dan kusut merusak jalur ini,
menyebabkan kekurangan Ach, sehingga pembelajaran dan memori
impairment.15 Hilangnya aktivitas Ach berkorelasi dengan
keparahan AD. Dasar dari pengobatan farmakologis dari AD
telah meningkatkan neurotransmisi kolinergik di
otak. Acetylcholinesterase adalah enzim yang mendegradasi Ach
di celah sinaps. Menghalangi enzim ini menyebabkan peningkatan
tingkat Ach dengan tujuan menstabilkan neurotransmission.16 Di
Amerika Serikat, empat cholinesterase inhibitor
yang disetujui untuk pengobatan AD yang tacrine, donepezil,
rivastigmine, dan galantamine.