The present study was undertaken to

The present study was undertaken to investigate the
hypo-/antihyperglycemic activity of M. indica leaf and
bark extracts in nondiabetic, type 2 and type 1 diabetic
model rats. Glibenclamide was used as a standard
drug for type 2 model rats and insulin for type 1 model
rats. It is well established that glibenclamide, a longacting
sulfonylurea, acts mainly by augmenting insulin
secretion. On the other hand, insulin activate glucose
uptake in various cells including muscles and
adipocytes, stimulates hexose uptake, lipogenesis and
inhibit lipolysis and stimulate protein synthesis.
Administration of glibenclamide to type 2 rats and
insulin to type 1 rats almost normalizes serum glucose
levels.
Our results demonstrate that all the extracts of M.
indica leaves and stem barks showed significant
antihyperglycemic effect in type 2 diabetic model rats
when the extracts were fed simultaneously with
glucose. Single oral administration of a dose of 250
mg/ kg body weight produces a potent and strong
hypoglycemic effect in type 2 rats. The obtained results
are supported by the finding of other investigators
(Sharma et al., 1997; Aderibigbe et al., 2001).
Hypoglycemic activity that is found when given with a
simultaneous glucose load in diabetic rats indicates
that the extracts may interfere with the intestinal
glucose absorption in the gut by various mechanisms
(Nahar et al.. 2000; Vinik and Wing, 1990; Lempcke,
1987). It may be postulated that the extracts of M. indica
might stimulate glycogenesis in the liver, which is
enhanced by feeding (Creutzfeld et al., 1979). This
effect was confirmed by Perpetus et. al where they
showed that blood glucose level of diabetic rats
consuming mango flour for 90 days decreased 66% in

Results (Indonesian) 1:

Penelitian ini dilakukan untuk menyelidikihipo- / antihyperglycemic aktivitas M. indica daun danekstrak kulit di nondiabetic, tipe 2 dan diabetes tipe 1model tikus. Glibenclamide digunakan sebagai standarobat untuk tipe 2 model tikus dan insulin untuk tipe 1 modeltikus. Hal ini juga ditetapkan bahwa glibenclamide, longactingsulfonilurea, bertindak terutama oleh peningkatan insulinsekresi. Di sisi lain, insulin Aktifkan glukosapengambilan dalam berbagai sel, termasuk otot-otot danadipocytes, merangsang uptake Heksosa, lipogenesis danmenghambat lipolisis dan merangsang sintesis protein.Administrasi glibenclamide tipe 2 tikus daninsulin untuk tipe 1 tikus hampir menormalkan glukosa serumtingkat.Hasil kami menunjukkan bahwa semua ekstrak m.indica daun dan batang menggonggong menunjukkan signifikanantihyperglycemic efek dalam tipe 2 diabetes model tikusKapan ekstrak diberi secara bersamaan denganglukosa. Satu pemberian oral dosis 250mg / kg berat badan menghasilkan yang kuat dan kuatEfek hipoglikemik pada tikus tipe 2. Hasil yang diperolehdidukung oleh penemuan penyidik lainnya(Sharma et al., 1997; Aderibigbe et al., 2001).Hipoglikemik kegiatan yang ditemukan ketika diberikan dengansimultan glukosa beban pada diabetes tikus menunjukkanbahwa ekstrak mungkin mengganggu dengan ususpenyerapan glukosa dalam usus oleh berbagai mekanisme(Nahar et al.. 2000; Vinik dan sayap, 1990; Lempcke,1987). ia mungkin mendalilkan bahwa ekstrak M. indicamight stimulate glycogenesis in the liver, which isenhanced by feeding (Creutzfeld et al., 1979). Thiseffect was confirmed by Perpetus et. al where theyshowed that blood glucose level of diabetic ratsconsuming mango flour for 90 days decreased 66% in