Conventional methods measure only a-priori selected EPs.In recent years generic chemical screening approaches
based on chromatography with full scan mass spectrometry have become increasingly popular to complement or
replace existing targeted methods (Hernández et al.,2012). In contrast to conventional targeted methods , the sample
is analyzed in a comprehensive way and in essence one can decide afterwards which EPs of interest to retrieve from
the raw data.This is an effective way of screening samples for very high numbers of EPs and an economical way to
pick up unexpected EPs for which application of quantitative targeted methods with all associated analytical quality
control is not justifiable. Other important advantages are the ability of retrospective detection of additional EPs
without the need for re-sampling/re-analys is of the sample,and detection and identification of unknowns. A hurdle
still to be taken to fully benefit from the potential of this technology in routine practice is the availability of adequate
data processing software and associated databases.